An exciting new discovery could help one-third of the world's population that suffers from tooth decay and cavities.
Are your teeth crying out for help? Do you need fillings but feel scared?
Bought a microscope slide on ebay. Here's tooth decay at 40x magnification under normal and polarised illumination. Decay in enamel and dentine much more obvious under polarised light #science #dental pic.twitter.com/gyslGnhAaa— Dr. David Mills (@DTL) 12 April 2018
Worry not, as scientists are working to bring a new drug that could make dental fillings a thing of the past.
80 % poor children in #buenosaires don’t know that the most important time to brush your teeth is at night . We’re #teaching them #dental #charity #health #hygiene #kids #saving #smiles pic.twitter.com/pNE2MKJTqH— TodosJuntos (@TodosJuntosArg) 8 June 2018
Initially developed and tested to treat Alzheimer’s disease, the drug called Tideglusib happens to promote the natural regrowth mechanism, allowing the tooth to repair the cavities itself.
"...when Tideglusib is applied to the injured spot on the tooth, it blocks the enzyme that usually stops dentin growth, glycogen synthase kinase (GSK-3), and the whole spot heals up by itself." https://t.co/PWZ6IKV9xo— Wednesday Atoms (@genericpanic) 15 January 2018
A new field in dentistry known as regenerative endodontics is in search of a natural solution that could help us get away from the need of dental fillings. Researchers in the U.K, led by Paul Sharpe, a professor of craniofacial biology at King’s College London, and his colleagues tested Tideglusib to stimulate the regrowth of teeth in mice and surprisingly, it worked.
“Using a drug that has already been tested in clinical trials for Alzheimer’s disease provides a real opportunity to get this dental treatment quickly into clinics,” Sharpe was quoted as saying by Telegraph.
In happier news, early trials of 'tooth repair drug' Tideglusib at King's College suggest it could replace fillings https://t.co/EJ5eJ8sYx3— Debbie Sorkin (@DebbieSorkin2) 10 January 2017
Tideglusib functions by stimulating stem cells in the pulp of teeth that is the source of new dentine. Dentine is the mineralized substance beneath the tooth enamel that is primarily affected by tooth decay.
Tideglusib : Drug that can Repair Cavities & Regrow Teeth by Stem Cells #Medicine #Science #Dentist #Stemcells #Health #Drug #Dental #Biology #Genetics #Biotech #Dna #Stem #Innovation #Bts https://t.co/HQT0mDJhYM pic.twitter.com/fA5bNl1ByV— Burak CALISKAN (@caliskan_burak) 14 January 2018
For the uninitiated, teeth can naturally regenerate dentine but only under certain circumstances. But even then, the tooth can only regrow a very thin layer naturally that isn't sufficient to cure the decay that has taken place.
Dental erosion is an irreversible loss of dental hard tissue, like enamel or dentine, caused by acidic foods and drinks dissolving away the surface of the tooth.— SADentalAssociation (@SADentalAssoc) 9 April 2018
Educational video via @bondistry pic.twitter.com/fyuacDzte9
Here comes the magic of tideglusib—it helps in the growth of dentine as it turns off the GSK-3 enzyme which is responsible for preventing dentine to form.
As a drug, tideglusib has already cleared the route to pass off as a safe treatment for Alzheimer’s. After Sharpe's team applied the drug on mice teeth, as early in the fourth week itself, they found that the dentine had filled out and the biodegradable sponge (made of collagen and placed in the space where the scientists had drilled the hole) had effectively vanished.
Read More About This Article: https://t.co/1x7NrPxFBm— Health Articles (@bjhealthtips) 27 December 2017
Scientists have found a drug that can repair cavities and regrow teeth - Tideglusib stimulates stem cells in the pulp of teeth, promoting new dentine production and natural tooth repair#health pic.twitter.com/qrkcN6g9tZ
“It greatly enhanced what the tooth tries to do naturally, but it does it in a much more robust way and much quicker,” Sharpe, who published the findings in the January 2018 issue of Scientific Reports, was quoted as saying by Newsweek.
Scientists of Kings College London discover that Alzheimer medicine Tideglusib grows stem cells in teeth. Making filling a thing of the past pic.twitter.com/H3sr6thZRC— ThaiMythbuster (@thaimythbuster) 10 January 2017
“The simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine,” Sharpe told Futurism.
While Sharpe and his team looked hopeful for tideglusib's usage in the future, several dental experts reflected the same excitement.
In an interview with Telegraph, Dr. Nigel Carter, CEO of the Oral Health Foundation, said: "This is an extremely interesting and novel approach which shows great promise and we will look forward to it being translated into the clinical application that could undoubtedly be a progressive step in the treatment of dental disease."
“While fillings have remained highly effective in repairing large cavities, they are susceptible to wear-and-tear and can occasionally be in need of repair and replacement. This presents problems as the dentist could have to remove and fill a larger area each time and after numerous treatments, the tooth may then have to be extracted," Dr. Carter added.
“Creating a more natural way for the tooth to repair itself could not only eliminate these issues but also be a far less invasive treatment option for patients. With dental phobia still being very common, using a natural way to stimulate the renewal of dentine could be an especially comforting proposal for these groups, for which undergoing treatment can often be a cause great anxiety,” he stated further.
Note: The article is not intended to provide any medical advice and has been based on ongoing studies. Kindly seek your doctor's help in case of any concern.